Models for estimation of the B-10 concentration after BPA-fructose complexinfusion in patients during epithermal neutron irradiation in BNCT

Purpose: To create simple and reliable models for clinical practice for est imating the blood B-10 time-concentration curve after p-boronophenylalanine fructose complex (BPA-F) infusion in patients during neutron irradiation i n boron neutron capture therapy (BNCT), Methods and Materials: BPA-F (290 mg BPA/kg body weight) was infused i.v. d uring two hours to 10 glioblastoma multiforme patients. Blood samples were collected during and after the infusion. Compartmental models and bi-expone ntial function fit were constructed based on the B-10 blood time-concentrat ion curve. The constructed models were tested with data from six additional patients who received various amounts of infused BPA-F and data from one p atient who received a one-hour infusion of 170 mg BPA/kg body weight. Results: The resulting open two-compartment model and bi-exponential functi on estimate the clearance of B-10 after 290 mg BPA/kg body weight infusion from the blood with satisfactory accuracy during the first irradiation fiel d (1 ppm, i.e., 7%). The accuracy of the two models in predicting the clear ance of B-10 during the second irradiation field are for two-compartment mo del 1.0 ppm (8%) and 0.2 ppm (2%) for bi-exponential function. The models p redict the average blood B-10 concentration with an increasing accuracy as more data points are available during the treatment. Conclusion: By combining the two models, a robust and practical modeling to ol is created for the estimation of the B-10 concentration in blood after B PA-F infusion. (C) 2000 Elsevier Science Inc.