Carcinoids of the ovary: An analysis of 329 reported cases

This evaluation was undertaken to supply precise and reliable detailed info rmation to investigators actively working in carcinoid and related gynecolo gical research fields. A statistical evaluation was performed on 329 cases of ovarian carcinoid re gistered in the Niigata Registry where world-wide information of gut-pancre atic endocrinomas has been maintained by a computer-analyzing system. Cases without individual identification or those recorded in groups were exclude d. The evaluation was carried out mainly by a comparison between two groups of cases with cystic teratoma/dermoid (Croup A) and those without such les ions (Group B). The former group consisted of 189 cases (57.4%) and the lat ter of 140 (42.6%). Statistically significant differences between these two groups were recogni zed in tumor size (44.7 mm vs 89.8 mm), rate of metastases (5.8% vs 22.1%), rate of hepatic involvement (2.1% vs 15.0%), incidence of associated carci noid syndrome (13.5% vs 22.9%) and 5-year survival rate (93.7% vs 84.0%). I nsular type and trabecular type carcinoids were recorded at an almost equal rate of one fourth ranging between 22% and 26% in either group. Another si gnificant difference in the incidence of carcinoid syndrome was evident bet ween the series of insular type and trabecular type carcinoids (38.9% vs 7. 8%). The present evaluation on ovarian carcinoids disclosed definite, statistica lly significant differences in various clinical and pathophysiologic aspect s between Group A and Group B, as well as between insular type and trabecul ar type histologic structures.