A series of diarylsubstituted oximes as potential substrate for new aldosereductase inhibitors

In the course of our research aimed at the discovery of new compounds actin g as aldose reductase inhibitors, we tested a series of some (E)- and (Z)-o megao-[[(aryldiazinylmethylene)amino]oxy]alkanoic acids, which were found t o have moderate in vitro inhibitory activity. On this basis we have now pre pared several new derivatives modified both at the length of the chain and at its terminal carboxylic group, together with compounds carrying various substituents at the phenyl ring. This paper describes their synthesis and b iological properties.