Further studies on polycyclic arene sulfides. Preparation and mutagenic activity of 9,10,10a,11a-tetrahydrotriphenyleno[1,2-b]thiirene, 1a,2,3,10b-tetrahydro-5H-thiereno[3,4]benzo[1,2-b]fluorene and 1a,2,3,11b-tetrahydroacenaphtho[1 ',2 ': 6,7] naphth[1,2-b] thiirene
J. Blum et al., Further studies on polycyclic arene sulfides. Preparation and mutagenic activity of 9,10,10a,11a-tetrahydrotriphenyleno[1,2-b]thiirene, 1a,2,3,10b-tetrahydro-5H-thiereno[3,4]benzo[1,2-b]fluorene and 1a,2,3,11b-tetrahydroacenaphtho[1 ',2 ': 6,7] naphth[1,2-b] thiirene, J HETERO CH, 37(5), 2000, pp. 1109-1112
The title compounds 6, 8 and 10, which are dihydroarene sulfides of the env
ironmental pollutants triphenylene, benzo[b]fluorene and benzo[k]fluoranthe
ne, have been synthesized from the corresponding epoxides and N,N-dimethylt
hioformamide. The mutagenicity of the episulfides has been investigated usi
ng Salmonella typhimurium strains TA98 and TA100. While compounds 6 and 10
were mutagenic, the tetrahydrobenzo[b]fluorene episulfide 8 was inactive.