Synthesis of acyclic nucleoside phosphonates as antiviral compounds

Authors
Wormstadt, F Brinckmann, U Gutschow, M Eger, K
Citation
F. Wormstadt et al., Synthesis of acyclic nucleoside phosphonates as antiviral compounds, J HETERO CH, 37(5), 2000, pp. 1187-1191
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
5
Year of publication
2000
Pages
1187 - 1191
Database
ISI
SICI code
0022-152X(200009/10)37:5<1187:SOANPA>2.0.ZU;2-2
Abstract
Reaction of 6-chloropyrimidines with diethyl [(2-aminoethoxy)methyl]phospho nate allows for a ready access to acyclic nucleoside phosphonates. A series of 5-substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV-1 and HSV -2) and human immunodeficiency virus (HIV-1). Some compounds showed weak an tiviral activity against HSV-1.