Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(3-methyl-1-piperazinyl)quinoxalines

Authors
Abdel-Jalil, RJ Al-Qawasmeh, RA Voelter, W Heeg, P El-Abadelah, MM Sabri, SS
Citation
Rj. Abdel-jalil et al., Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(3-methyl-1-piperazinyl)quinoxalines, J HETERO CH, 37(5), 2000, pp. 1273-1275
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
5
Year of publication
2000
Pages
1273 - 1275
Database
ISI
SICI code
0022-152X(200009/10)37:5<1273:SAPOS2>2.0.ZU;2-G
Abstract
The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3- 11) were synthesized for bioassay via reaction of 1,2-diamino-4-fluoro-5-(4 -methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compo unds. However, none of the tested compounds 3-11 showed significant in vitr o activity against E. coli ATCC 11229, S. aureus ATCC6538 and C. albicans S ATCC10231.