Carbocyclic 5 '-norcytidine (5 '-noroarbodine)

Authors
Hegde, VR Seley, KL Schneller, SW
Citation
Vr. Hegde et al., Carbocyclic 5 '-norcytidine (5 '-noroarbodine), J HETERO CH, 37(5), 2000, pp. 1361-1362
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
5
Year of publication
2000
Pages
1361 - 1362
Database
ISI
SICI code
0022-152X(200009/10)37:5<1361:C5'('>2.0.ZU;2-U
Abstract
A preparation of (1'R,2'S,3'R,4'S)-1-(2',3',4'-trihydroxycyclopent-1'-yl)-1 H-cytosine (5'-norcarbodine, 3) has formally been achieved in 2 steps from (+)-(1R,4S)-4-hydroxy-2-cyclopenten-1-yl acetate (4) and cytosine. The L-li ke enantiomer of 3 (that is, 6) is also reported using the enantiomer of 4 (that is, 7). In evaluating 3 and 6 for antiviral potential against a numbe r of viruses, compound 3 was found to have activity towards Epstein-Barr vi rus (EBV).