THE EFFECT OF COAGULATION PARAMETERS ON THE PLACENTAL RESPIRATORY ANDNUTRITIVE FUNCTION IN WOMEN HAVING CHRONIC HYPERTENSION WITH SUPERIMPOSED PREECLAMPSIA
J. Djelmis et al., THE EFFECT OF COAGULATION PARAMETERS ON THE PLACENTAL RESPIRATORY ANDNUTRITIVE FUNCTION IN WOMEN HAVING CHRONIC HYPERTENSION WITH SUPERIMPOSED PREECLAMPSIA, Collegium antropologicum, 21(1), 1997, pp. 127-137
The aim of this study was to explore the relationship between coagulat
ion and fibrinolytic system parameters with nutritive and respiratory
placental function. We have analysed 79 pregnant women of which 39 wit
h severe preeclampsia finder group) and 41 healthy pregnant women. Whe
n comparing the study groups in third trimester; significantly lower p
latelet counts, fibrinogen values and antithrombine III values have be
en found in the index group compared to the control group. Factor VIII
Levels were not found to be significantly different. The central grou
p revealed significantly higher levels of coagulation factors II, V an
d VIII, compared to the index group. The increase of FDP, reduction of
fibrinogen and increase of fibrinolysis in index group, when compared
to the control group of healthy pregnant women are the reflection of
the intravascular fibrin deposition that leeds to the described coagul
ation changes and consecutively to the foetal growth retardation. Indi
rect evidence are the correlation between newborns' weight and fibrino
gen levels/fibrinolytic activity.