THE EFFECT OF COAGULATION PARAMETERS ON THE PLACENTAL RESPIRATORY ANDNUTRITIVE FUNCTION IN WOMEN HAVING CHRONIC HYPERTENSION WITH SUPERIMPOSED PREECLAMPSIA

The aim of this study was to explore the relationship between coagulat ion and fibrinolytic system parameters with nutritive and respiratory placental function. We have analysed 79 pregnant women of which 39 wit h severe preeclampsia finder group) and 41 healthy pregnant women. Whe n comparing the study groups in third trimester; significantly lower p latelet counts, fibrinogen values and antithrombine III values have be en found in the index group compared to the control group. Factor VIII Levels were not found to be significantly different. The central grou p revealed significantly higher levels of coagulation factors II, V an d VIII, compared to the index group. The increase of FDP, reduction of fibrinogen and increase of fibrinolysis in index group, when compared to the control group of healthy pregnant women are the reflection of the intravascular fibrin deposition that leeds to the described coagul ation changes and consecutively to the foetal growth retardation. Indi rect evidence are the correlation between newborns' weight and fibrino gen levels/fibrinolytic activity.