Distributed and partially separate pools of neurons are correlated with two different components of the gill-withdrawal reflex in Aplysia

We compared the spike activity of individual neurons in the Aplysia abdomin al ganglion with the movement of the gill during the gill-withdrawal reflex . We discriminated four populations that collectively encompass approximate ly half of the active neurons in the ganglion: (1) second-order sensory neu rons that respond to the onset and offset of stimulation of the gill and ar e active before the movement starts; (2) neurons whose activity is correlat ed with the position of the gill and typically have a tonic output during g ill withdrawal; (3) neurons whose activity is correlated with the velocity of the movement and typically fire in a phasic manner; and (4) neurons whos e activity is correlated with both position and velocity. A reliable predic tion of the position of the gill is achieved only with the combined output of 15-20 neurons, whereas a reliable prediction of the velocity depends on the combined output of 40 or more cells.