Honulactones: New bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena

Authors
Jimenez, JI Yoshida, WY Scheuer, PJ Lobkovsky, E Clardy, J Kelly, M
Citation
Ji. Jimenez et al., Honulactones: New bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena, J ORG CHEM, 65(21), 2000, pp. 6837-6840
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
65
Issue
21
Year of publication
2000
Pages
6837 - 6840
Database
ISI
SICI code
0022-3263(20001020)65:21<6837:HNBSFT>2.0.ZU;2-Z
Abstract
From the dichloromethane/2-propanol (1:1) extract of the Indonesian marine sponge Strepsichordaia aliena, twelve new 20,24-bishomoscalarane sesterterp enes, honulactones A-L (1-12) were isolated. Molecular structures were secu red by spectroscopic methods,accurate mass measurements, and X-ray analysis . Honulactones A (1), B (2), C (3), and D (4) exhibit cytotoxycity against P-388, A-549 HT-29, and MEL-28 (IC50 1 mug/mL).