A. Fernandez-gacio et al., Synthesis of new aromatic (C17-C20)-locked side-chain analogues of calcitriol (1 alpha,25-dihydroxyvitamin D-3), J ORG CHEM, 65(21), 2000, pp. 6978-6983
The synthesis of four new analogues of calcitriol (1 alpha ,25-(OH)(2)-D-3)
possessing aromatic and conjugated double bond units at the side chain are
described. The triene system is introduced using the Lythgoe-Hoffmann La R
oche convergent Wittig-Horner approach. The key steps in the preparation of
the requisite upper fragments are the introduction of the side chain with
the E-conjugated aromatic system and its photochemical conversion to the Z
counterpart.