ALLOGENIC TRANSPLANTATION OF MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS - TOWARDS TAILORED CELL THERAPY

Mobilized peripheral blood prognitor cells (PBPC) are increasingly bei ng used instead of bone marrow for allogeneic transplantation. The pre sent article will briefly review important aspects of allogeneic PBPCT including donor safety, timing of leukapheresis, factors influencing the yield, cellular composition of PBPC allografts, hematopoietic capa city of allogeneic PBPC, and graft-versus-host and graft-versus-leukem ia activities. It will particularly focus on the perspectives opened b y PBPC for graft engineering and cell therapy. (C) 1997 Elsevier Scien ce Ireland Ltd.