Telangiectasia macularis eruptiva perstans and multiple myeloma

The association of mast cell diseases and some hematologic malignancies, us ually myeloproliferative disorders, myelodysplastic syndromes, and acute le ukemia is well recognized. We report the case of a patient with telangiecta sia macularis eruptiva perstans, a rare form of cutaneous mastocytosis, and multiple myeloma, an association that has been described only twice in the literature. Parallel improvement of both conditions was observed under che motherapy regimens for multiple myeloma. Pathogenesis remains unclear, alth ough the abnormalities in the c-kit pathway may play a role in the prolifer ation of cells from both lineages.