Background and Objectives. Postdural puncture headache can recur follo
wing an epidural blood patch but usually does so within the first week
. However, a late recurrence was encountered in a 31-year-old woman wi
th probable lupus vasculitis. Methods. The patient underwent a diagnos
tic lumbar puncture and suffered a postdural puncture headache. She wa
s treated with an epidural blood patch and had complete resolution of
her headache. Five weeks later, she suffered a sudden recurrence of an
identical headache and underwent a repeat epidural blood patch. Resul
ts. The second headache, like the first, was immediately and completel
y resolved. Conclusions. A review of risk factors for postdural punctu
re headache and the role of an epidural blood patch suggests a possibl
e explanation for the late recurrence in this case.