The oxidation of naltrexone (compound used in the treatment of opioid
addiction) on carbon paste electrodes has been studied using voltammet
ric techniques under semi-infinite linear diffusion and hydrodynamic c
onditions. A simple ''in situ'' electrode pretreatment is proposed to
obtain a good reproducibility of the current signal. Subsequently, the
current was measured and the concentration of naltrexone present coul
d be determined. A linear calibration plot from 7x10(-6) to 10(-4)M wa
s obtained by using a scan rate of 50 mV/s. The method was succesfully
applied to the determination of the compound in pharmaceuticals.