Decline in the HIV-1 isolation rate in Japan: A 12-year observation

Authors
Nakasone, T Takamatsu, J Watanabe, K Naganawa, S Someya, K Yoshino, N Kaizu, M Ohsu, T Takizawa, M Izumi, Y Kawahara, M Hara, T Fujimura, Y Yamada, K Nagai, Y Yamazaki, S Honda, M
Citation
T. Nakasone et al., Decline in the HIV-1 isolation rate in Japan: A 12-year observation, MICROB IMMU, 44(11), 2000, pp. 949-952
Citations number
12
Categorie Soggetti
Microbiology
Journal title
MICROBIOLOGY AND IMMUNOLOGY
ISSN journal
03855600 → ACNP
Volume
44
Issue
11
Year of publication
2000
Pages
949 - 952
Database
ISI
SICI code
0385-5600(2000)44:11<949:DITHIR>2.0.ZU;2-4
Abstract
Since 1988, we have isolated HIV-1 from 614 HIV-1-infected persons (total s ample=2,785) in Japan, During the past 12 years, we have found a decline in the HIV-1 isolation rate in Japan, with two identifiable turning points, 1 991-1992 and 1996-1997, The two turning points correspond to shifts in anti -HIV-1 therapy. These findings suggest that HIV-1 in Japan is currently bio logically well controlled, probably due to anti-HIV-1 therapy. On the other hand, this decline is inconsistent with the recent increase of genetic dru g-resistant HIV-1 in Japan, Further studies are needed to clarify mechanism s that might explain the discrepancy.