How does Parkinson's disease affect quality of life? A comparison with quality of life in the general population

BACKGROUND: Adequate provision of appropriate healthcare resources for pati ents with chronic neurologic disorders such as Parkinson's disease (PD) req uires knowledge of the impact of the illness on their life. Quality of life (QoL) instruments measure the impact of the disease on general wellbeing t hat cannot be fully appreciated by clinical rating scales and allow compari sons with other patient groups and the general population. OBJECTIVES: To assess QoL in a population-based sample of patients with PD in different disease stages in comparison with the general population. METHODS: All 124 patients with PD seen in a population-based study on the p revalence of parkinsonism in the London area were asked to complete a QoL b attery including the EuroQoL 5D (EQ-5D), the Medical Outcome Study Short Fo rm (SF 36), and the 39-item Parkinson's Disease questionnaire (PDQ-39). An interview and complete neurologic examination, including the Hoehn and Yahr scale, were performed on the same day. The patients' QoL scores were compa red with published QoL norms from the United Kingdom population. RESULTS: Quality of life, as measured by the PDQ-39, the EQ-5D, and the phy sical summary of the SF 36, deteriorated significantly with increasing dise ase severity. The greatest impairment was seen in the areas related to phys ical and social functioning, whereas reports of pain and poor emotional adj ustment had similar prevalence in patients with PD and the general populati on. The impairment of QoL was seen in all age groups and was similar for me n and women, but the differences between patients with PD and the general p opulation were most marked in the younger patient groups. CONCLUSIONS: Parkinson's disease interferes with various aspects of QoL, pa rticularly those related to physical and social functioning. This informati on should be taken into account in the clinical management and planning and allocation of healthcare resources to this population.