Pulmonary hyalinising granuloma: A case report and literature review

This is a case of a rare lung disease known as pulmonary hyalinising granul oma, which is usually discovered incidentally on chest radiographs and pose s diagnostic difficulties but has an excellent prognosis. In this case a 75 -year-old man had a 6-year history of undiagnosed, enlarging, bilateral den se apical infiltrates. The patient died from his tobacco smoke-related emph ysema, which led to diagnosis of the lesion. At autopsy both lungs showed w ell-defined apical, hard, grey-white masses covered by a rind of thickened adherent pleura. Histologically, the lesion was composed of dense, haphazar d lamellar, keloid-like collagen concentrically arranged around blood vesse ls with extension into the pleura and perivascular collections of lymphocyt es and plasma cells.