Intragastric beta-casomorphin(1-7) attenuates the suppression of fat intake by enterostatin

The current experiments were designed to compare the feeding response to en terostatin and beta -casomorphin(1-7) injected intragastrically. Sprague-Da wley rats with a gastric cannula were allowed to chose from high-fat diet ( HF) or low-fat diet (LF) in separate jars. Enterostatin injected intragastr ically into overnight fasted rats caused a U-shaped dose-dependent reductio n in the intake of the HF diet for the first two hours after infusion but h ad no effect on the LF intake. beta -Casomorphin(1-7) stimulated the intake of the HF diet but had no effect on the LF diet. Finally, beta -casomorphi n(1-7) blocked the inhibitory effect of enterostatin on HF intake in fasted rats. (C) 2000 Elsevier Science inc. AU rights reserved.