M. Hackel et al., The partial molar volumes of some tetra- and pentapeptides in aqueous solution: a test of amino acid side-chain group additivity for unfolded proteins, PHYS CHEM P, 2(21), 2000, pp. 4843-4849
Ten new peptides with the amino acid sequences glycyl-X-Y-glycine and glycy
l-X-Y-Z-glycine, where X, Y and Z are amino acids with neutral side-chains,
have been synthesized and the partial molar volumes at infinite dilution,
V(2)degrees, have been determined for all these peptides in aqueous solutio
n at 298.15 K. For several of the peptides, V(2)degrees data have also been
obtained over the temperature range 283.15 to 363.15 K using a scanning de
nsimetric method. The V(2)degrees results obtained are compared with those
calculated using the principle of group additivity and the group partial mo
lar volumes we have derived in earlier work. We have shown that our group p
artial molar volumes can be used to reliably predict the partial molar volu
mes over a wide temperature range of polypeptides that have neutral amino a
cid side-chains.