Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum

Authors
Bezerra, MAC Leal-Cardoso, JH Coelho-de-Souza, AN Criddle, DN Fonteles, MC
Citation
Mac. Bezerra et al., Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum, PHYTOTHER R, 14(7), 2000, pp. 549-551
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHYTOTHERAPY RESEARCH
ISSN journal
0951418X → ACNP
Volume
14
Issue
7
Year of publication
2000
Pages
549 - 551
Database
ISI
SICI code
0951-418X(200011)14:7<549:MAAEOT>2.0.ZU;2-W
Abstract
The effects of the essential oil of Alpinia speciosa Schum (EOAS) on rat il eum were studied. EOAS (0.1-600 mug/mL) reversibly relaxed ileal basal tonu s, Submaximal contractions induced by 60 mM KCI or acetylcholine were conce ntration dependently inhibited by EOAS with similar IC50 values (similar to 44 and 48 mug/mL, respectively). These results show that EOAS possesses bo th relaxant and antispasmodic actions in the ileum, Copyright (C) 2000 John Wiley & Sons, Ltd.