Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium

Further study an the chloroform-soluble portion of the root bark of Zanthox ylum schinifolium led to the isolation of eight new coumarins: methylschini lenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydrox yschininallyloI (4), hydroxyepoxycollinin ii (5), schinitrienin (6), schini nallylone (7), and isoschinilenol (8), along with twenty-six known compound s including fourteen coumarins, and nine alkaloids. The structural elucidat ion was determined by spectroscopic data. Among the isolates, terpenyl-coum arins and furoquinolines were the active constituents with antiplatelet agg regation in vitro and collinin (10) showed significant anti-HBC DNA replica tion activity.