Two new gallotannins, pistafolins A (1) and B (2), were isolated from the l
eaf extract of Pistacia weinmannifolia. Their structures were determined by
spectral methods. Four known gallotannins (3-6), seven known flavonoid gly
cosides (7-13), along with 1-O-beta -D-(6'-O-galloyl)-glucopyranosyl-ethoxy
-5-hydroxybenzene (14), gallic acid (15), methyl gallate (16), (+)-catechin
(17), and (+)-gallocatechin (18), were also isolated. Some of these compou
nds were tested for their cytotoxicity toward K562 cells, and two small mol
ecular phenolic compounds, 15 and 18, showed significant inhibitory effects
with IC50 Values less than 5 mug/ml.