Interaction of organo-tin derivatives with gramicidin ion-conducting channel

The objective of this study was to determine the interaction of organo tin (IV) compounds with a gramicidin ion-conducting channel incorporated into p lanar lipid bilayers. The relative change of trans membrane current was use d as a parameter for estimating the above interaction. This measured parame ter was in good relationship with physicochemical - partition coefficients (logP) and topological - total surface area (TSA) properties of the compoun ds under study. The presented model might be applied for estimation of toxi city of organo metallic derivatives.