Combined von Willebrand disease and factor XII deficiency (vWD San Diego) in the dog and humans

In 1976 Cramer et al. described a new human variant of von Willebrand disea se (vWD) characterized by typical findings of vWD and concomitant reduced l evel of factor WI. This combination was designated von Willebrand disease S an Diego. We found this combination as well in two human families and in a dog. A German wirehaired pointer showed increased posttraumatic bleeding in combination with reduced levels of the factor VIII/von Willebrand factor c omplex (vWD type I) and a decrease of factor XII:activity to 35 per cent Th us, certain uncommon findings are not specific for humans. In accordance wi th other authors it is questionable whether the vWD San Diego is an indepen dent entity of vWD.