Highly specific methods are required for the diagnostic workup of focal hep
atic lesions, since benign circumscribed liver changes are very common. Alt
hough cross-sectional imaging techniques have a high diagnostic accuracy, r
adionuclide imaging techniques such as colloid, red blood cell, or hepatobi
liary scan are commonly performed when a benign lesion is assumed since the
se permit a definite diagnosis with high specificity. The diagnosis of a pr
imary or secondary malignant liver tumor, however, usually relies on radiol
ogical imaging techniques alone, supported by needle biopsy. Whether positr
on emission tomography as a primary or supplementary diagnostic tool will h
ave a role in the routine staging of maligna nt tumors remains to be determ
ined.