Quantitative assessment of renal function with magnetic resonance imaging

Aim. To show the potential of various methods in magnetic resonance imaging for the evaluation of renal function. Material and Methods. A combined assessment of renal morphology, renal hemo dynamics and function is proposed. Various techniques are explained, includ ing multiphasic 3D gadolinium MR angiography, MR phase-contrast flow measur ements, quantitative perfusion measurements with intravascular contrast age nts, and MR renography and MR urography. The use of these techniques is dem onstrated for renovascular diseases. Results. The combined use of these techniques allows renal artery stenosis to be accurately detected and evaluation of renal blood flow, perfusion, gl omerular filtration rate, and renal excretion. Based on true quantitative p arameters,the hemodynamic and functional significance of the stenosis can b e assessed. Renovascular diseases can be differentiated from renoparenchyma l disease. Conclusion. For the assessment of renal function,functional magnetic resona nce imaging techniques are an important alternative to nuclear medicine. Th e predictive value regarding the effect of revascularization is currently u nder investigation.