Penarolide sulfates A(1) and A(2), new alpha-glucosidase inhibitors from amarine sponge Penares sp.

Authors
Nakao, Y Maki, T Matsunaga, S van Soest, RWM Fusetani, N
Citation
Y. Nakao et al., Penarolide sulfates A(1) and A(2), new alpha-glucosidase inhibitors from amarine sponge Penares sp., TETRAHEDRON, 56(46), 2000, pp. 8977-8987
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
46
Year of publication
2000
Pages
8977 - 8987
Database
ISI
SICI code
0040-4020(20001110)56:46<8977:PSAAAN>2.0.ZU;2-Z
Abstract
Penarolide sulfates A(1) (1) and A(2) (2) have been isolated as alpha -gluc osidase inhibitors from a marine sponge Penares sp.(1) Their structures inc luding absolute stereochemistry were determined to be unique 30- and 31-mem bered macrolides encompassing a proline residue and three sulfate groups by interpretation of spectral data and chemical degradation. Penarolide sulfa tes Al (1) and A2 (2) inhibit alpha -glucosidase with IC50 values of 1.2 an d 1.5 mug/mL, respectively. (C) 2000 Elsevier Science Ltd. All rights reser ved.