In vivo microdialysis as a tool for monitoring pharmacokinetics

Citation
Dj. Weiss et al., In vivo microdialysis as a tool for monitoring pharmacokinetics, TRAC-TREND, 19(10), 2000, pp. 606-616
Citations number
52
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN journal
01659936 → ACNP
Volume
19
Issue
10
Year of publication
2000
Pages
606 - 616
Database
ISI
SICI code
0165-9936(200010)19:10<606:IVMAAT>2.0.ZU;2-5
Abstract
Microdialysis sampling is used to monitor the pharmacokinetics and distribu tion of drugs and endogenous compounds in vivo. This article discusses adva ntages of microdialysis performed in vivo compared to traditional sampling methods, In addition, analytical considerations are discussed with a focus on practical aspects of microdialysis, Recent advances and applications of in vivo microdialysis with emphasis on pharmacokinetics are described. (C) 2000 Elsevier Science B.V. All rights reserved.