Rp. Sherwin et al., Centriacinar region inflammatory disease in young individuals: a comparative study of Miami and Los Angeles residents, VIRCHOWS AR, 437(4), 2000, pp. 422-428
Citations number
28
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
Semiquantitative measurements of chronic inflammation of the centriacinar r
egion (proximal acinus of lung) were compared between 20 Miami and Is Los A
ngeles residents (ages 11-30 years) for whom smoking histories were availab
le. Mean extent and severity scores of four lung sites were higher for Los
Angeles than Miami residents, with effect of city statistically significant
for extent (P=0.02). Also, maximum scores for extent and severity by city
were significantly greater for Los Angeles residents (P=0.02, each), but no
t by smoking history. Smokers did have higher scores for mean extent and se
verity (by lung site and smoking history), but neither this nor inclusion o
f smoking and city in the model reached significance. With respect to maxim
um extent and maximum severity scores, a stratified comparison of cities by
smoking history showed a trend (not significant) toward higher scores for
Los Angeles residents. Mean extent and severity scores for the lower lobe w
ere higher for basilar sections than for apical sections teach P<0.001). Cu
mulative data indicate that expanded pathologic studies are essential for e
fforts to complete a convergence of epidemiological and experimental data i
mplicating exceedences of the Federal ozone standard as a contributor to hu
man lung injury.