Tg. Fanning et al., Influenza A virus neuraminidase: Regions of the protein potentially involved in virus-host interactions, VIROLOGY, 276(2), 2000, pp. 417-423
Phylogenetically informative amino acid positions (PIPs) were identified in
influenza A neuraminidases of subtypes N1 and N2. Neuraminidase evolves in
a lineage-specific way as the virus adapts to a new host or changes to eva
de the host's immune system. Thus, many PIPs undoubtedly identify positions
involved in virus-host interactions. Phylogenetically important regions (P
IRs) are defined as several PIPs near one another. There are 15 PIRs on N1
and 12 on N2, seven of which are shared between the two subtypes. Many PIRs
are coincident with antigenic or glycosylation sites. Other PIRs may repre
sent additional antigenic sites or may be involved in other aspects of viru
s-host biology. (C) 2000 Academic Press.