Spontaneous regression of intrahepatic lesions mimicking metastatic disease

This is a case report of a 53-year-old male with chronic hepatitic C infect ion presenting with weight loss and elevated liver function tests. Repeated ultrasonography, computed tomography and magnet resonance imaging showed m ultiple intrahepatic lesions suggestive of metastatic disease. Repeated ult rasound-guided biopsies from the lesions as well as from the adjacent norma l appearing liver tissue revealed no malignancy but showed inflammation and significant fibrotic tissue, consistent with chronic hepatitis C. 2 years after the first admission liver function tests were all within the normal r ange and remained so until today. Computed tomography at that time showed c omplete remission of all intrahepatic lesions. The exact diagnosis remained elusive but the rare case of reversible focal fibrosis is the most likely cause of these spontaneously regressive lesions.