The authors investigated the role of self-reported life satisfaction in mor
tality with a prospective cohort study (1976-1995). A nationwide sample of
healthy adults (18-64 years, n = 22,461) from the Finnish Twin Cohort respo
nded to a questionnaire about life satisfaction and known predictors of mor
tality in 1975. A summary score for life satisfaction (LS), defined as inte
rest in life, happiness, loneliness, and general ease of living (scale rang
e, 4-20), was determined and used as a three-category variable: the satisfi
ed (LS, 4-6) (21%), the intermediate group (LS, 7-11) (65%), and the dissat
isfied (LS, 12-20) (14%). Mortality data were analyzed with Cox regression.
Dissatisfaction was linearly associated with increased mortality. The age-
adjusted hazard ratios of all-cause, disease, or injury mortality among dis
satisfied versus satisfied men were 2.11 (95% confidence interval (CI): 1.6
8, 2.64), 1.83 (95% CI: 1.40, 2.39), and 3.01 (95% CI: 1.94, 4.69), respect
ively. Adjusting for marital status, social class, smoking, alcohol use, an
d physical activity diminished these risks to 1.49 (95% CI: 1.16, 1.92), 1.
35 (95% CI: 1.01, 1.82), and 1.93 (95% CI: 1.19, 3.12), respectively. Dissa
tisfaction was associated with increased disease mortality, particularly in
men with heavy alcohol use (hazard ratio = 3.76, 95% CI: 1.61, 8.80). Wome
n did not show similar associations between life satisfaction and mortality
. Life dissatisfaction may predict mortality and serve as a general health
risk indicator. This effect seems to be partially mediated through adverse
health behavior.