CD8-depleted donor leukocyte transfusions for cytomegalovirus antigenemia in patient with acute lymphoblastic leukemia treated with allogeneic CD34(+) cell transplantation

A 24-year-old man with acute lymphoblastic leukemia received an allogeneic CD34(+) cell transplant from an HLA-mismatched sibling because of refractor y disease. The CD34(+) cells were enriched by the immunomagnetic method. On e month after the transplant his situation became complicated due to cytome galovirus (CMV) antigenemia, which was resistant to treatment with ganciclo vir. He was treated with CD8(+) cell depleted donor lymphocyte transfusions (CD8-depleted DLT). After CD8-depleted DLT, the CMV antigenemia disappeare d completely. This case report suggested that CD8 depleted DLT was an effec tive therapy for CMV antigenemia after allogeneic CD34(+) cell transplantat ion. (C) 2000 Wiley-Liss, Inc.