G. Di Vita et al., Tension-free hernia repair is associated with an increase in inflammatory response markers against the mesh, AM J SURG, 180(3), 2000, pp. 203-207
BACKGROUND: The purpose of this study was to evaluate the involvement of in
flammatory mediators in patients undergoing Lichtenstein tension-free herni
oplasty (LH) using polypropylene prosthetic materials or conventional Bassi
ni hernia repair (BH),
METHODS: Thirty patients male with unilateral inguinal hernia without compl
ications or recurrence were included in this study. Randomly, patients unde
rwent LH or BH, Peripheral venous bloods samples were collected 24 hours pr
ior to surgery and then 6, 24, 48 and 168 hours postoperatively,
RESULTS: We present evidences that LH patients showed a higher increased se
rum level of fibrinogen, C-reactive protein, alpha-1-antitrypsin, and inter
leukin-6 than BH patients. Postoperative visual analogue scales for pain we
re reduced on mobilization for patients undergoing LH compared with BH. Neu
trophils were significantly increased only in LH compared with baseline. Ce
ruloplasmin, transferrin, and albumin levels were unmodified after BH or LH
.
CONCLUSIONS: In conclusion our data show that although LH induces less pain
and more rapid postoperative recovery, it is associated with an higher inf
lammatory response compared with BH, likely due to polypropylene mesh, Am J
Surg. 2000;180:203-207. (C) 2000 by Excerpta Medica, Inc.