Acute generalized exanthematic pustulosis (AGEP) in a patient treated withfurosemide

Background: Although they appear more rarely than electrolyte disturbances, cutaneous reactions are important adverse effects of furosemide. This is p articularly true for bullous skin eruptions, because they may be life-threa tening. Case Report: We describe a patient who developed acute generalized exanthematic pustulosis (AGEP) during treatment with furosemide. Because th e patient had developed similar skin eruptions during treatment with furose mide years before, furosemide was considered the most likely cause of this reaction. The short period of time between exposure to furosemide and the a ppearance of the skin reaction, as well as a positive lymphocyte transforma tion test, suggest an immunological mechanism of the skin disease. Conclusi on: AGEP is a possible cutaneous side effect of furosemide.