We review here two unique organelles from Trypanosoma cruzi. One of them is
the acidocalcisome, cytoplasmic vacuoles containing a very high Ca2+ conce
ntration and a Ca2+ - H+ translocating ATPase activity, present in all tryp
anosomatids. The other organelle is the reservosome, site of accumulation o
f endocytosed macromolecules, very rich in cystein proteinase, that is pres
ent only in epimastigote forms of trypanosomes belonging to the Schyzotrypa
num sub-genus.