The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional

Authors
Parsian, AJ Sheren, JE Tao, TY Goswami, PC Malyapa, R Van Rheeden, R Watson, MS Hunt, CR
Citation
Aj. Parsian et al., The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional, BBA-GENE ST, 1494(1-2), 2000, pp. 201-205
Citations number
14
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1494
Issue
1-2
Year of publication
2000
Pages
201 - 205
Database
ISI
SICI code
0167-4781(20001115)1494:1-2<201:THHGAT>2.0.ZU;2-J
Abstract
The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23 .1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene a nd cDNA copies of the mRNA indicate the gene is non-functional. Moreover, m ouse homologues of Hsp70B/B' were not detected by Southern blot analysis, s uggesting Hsp70B/B' arose from either Hsp70-1 or Hsp70-2 after the divergen ce of mice and humans. (C) 2000 Elsevier Science B.V. All rights reserved.