3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effecton neuropeptide secretion

The aim of the present study was to describe the synthesis of a trimethyl c yclohexenonic long chain fatty alcohol (t-CFA), and analyze its biological activity. Specifically, 3-(15-hydroxypentadecyl)-2,4 4-trimethyl-2-cyclohex en-1-one, the I-CPA containing 15 carbon atoms on the side chain (t-CFA n = 15) stimulated arginine vasopressin secretion in nerve terminals of the ne urohypophysis. This effect was inhibited by extracellular calcium depletion , which suggets that t-CFA n=15 stimulates neuropeptide secretion through a calcium-dependent exocytosis mechanism. (C) 2000 Published by Elsevier Sci ence Ltd.