Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat

Authors
Mautes, AEM Noble, LJ
Citation
Aem. Mautes et Lj. Noble, Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat, BRAIN RES, 883(2), 2000, pp. 233-237
Citations number
33
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
883
Issue
2
Year of publication
2000
Pages
233 - 237
Database
ISI
SICI code
0006-8993(20001117)883:2<233:COHAHO>2.0.ZU;2-D
Abstract
HSP70 and heme oxygenase-1 (HO-1) are thought to be markers of cell injury and oxidative stress, respectively. We have immunolocalized these proteins in the spinal cord at 1-14 days after contusion. HSP70 and HO-1 were co-ind uced in glia and macrophages within the injured segment at all time points. This co-induction may reflect complementary functions that serve to protec t these cells as they respond to the postcontusional environment. (C) 2000 Elsevier Science B.V. All rights reserved.