Mixing effects on product particle characteristics from semi-batch crystalprecipitation

The effects of different mixing and process parameters on the formation of crystals obtained from semi-batch precipitation are reported. The influence of feed time, feed concentration, feed tube diameter and impeller type on particle morphology of calcium oxalate and calcium carbonate respectively a re discussed. In addition, a hybrid mixing-CFD model, the Segregated Feed M odel (SFM), is used to predict the influence of process conditions on produ ct particle size via the population balance. Experimental results for the p article size using 1, 5 and 251 reactors show reasonable agreement with mod el predictions.