Rapid separation of basic drugs by nonaqueous capillary electrophoresis

Nonaqueous capillary electrophoresis (NACE) has been used to achieve rapid separations of basic drugs. A high electric field was obtained by using sho rt capillaries, Baseline separations of basic drugs, including amphetamines , tropane alkaloids and local anesthetics, were achieved in I min by select ion of the appropriate organic solvent and electrolyte composition. Thus, h igh-throughput analyses can be performed. Peak efficiency up to 9154 theore tical plates s(-1) was achieved in a separation performed at 923Vcm(-1). No discernible loss in resolution was observed when a conventional capillary (64.5cm) was replaced by a short (32.5cm) capillary.