Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase

Authors
Hyun, MH Han, SC Jin, JS Lee, W
Citation
Mh. Hyun et al., Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase, CHROMATOGR, 52(7-8), 2000, pp. 473-476
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHROMATOGRAPHIA
ISSN journal
00095893 → ACNP
Volume
52
Issue
7-8
Year of publication
2000
Pages
473 - 476
Database
ISI
SICI code
0009-5893(200010)52:7-8<473:SOTSOR>2.0.ZU;2-E
Abstract
A chiral stationary phase derived from (+)-( 18-crown-6)-2,3,11,12-tetracar boxylic acid has been successfully used for the direct separation of the en antiomers of racemic fluoroquinolines containing a primary amino group bein g investigated as antibacterial agents. The chromatographic resolution beha vior was found to depend on the content and the type of acidic and organic modifiers in the mobile phase and on the column temperature.