COMBINED GASTRIC AND ILEOCECAL TOXICITY (SERPIGINOUS ULCERS) AFTER ORAL KAYEXALATE IN SORBITOL THERAPY

Kayexalate (Roxane Labs, Columbus, OH) in sorbitol is commonly adminis tered by the oral and rectal route for the treatment of hyperkalemia i n patients with renal failure. It is believed to have minimal toxicity because if functions as a cation exchanger and is not absorbed. We he rein report on a patient who developed identical serpiginous ulcers in the stomach and the terminal ileum after the use of Kayexalate. We be lieve that this drug could have significant gastrointestinal toxicity in specific patient groups and suggest tentative guidelines, both for the identification of such patients and for the safer use of Kayexalat e in these circumstances. (C) 1997 by the National Kidney Foundation, Inc.