Prognostic significance of cyclin E overexpression in laryngeal squamous cell carcinomas

Cyclin E plays a pivotal role in the regulation of G(1)-S transition and re lates to malignant transformation of cells. However, the clinical significa nce of cyclin E in patients with laryngeal squamous cell carcinoma (LSCC) r emains unknown. We examined the expression of cyclin E in 102 patients with LSCC and analyzed its relation to clinicopathological parameters, cell pro liferation, and clinical outcome. Cyclin E overexpression was observed in 5 4 cases (52.94%) of LSCC and was significantly correlated with the tumor si te (P = 0.012), tumor size (P = 0.006), poor differentiation (P = 0.026), l ymph node metastasis (P = 0.012), and advanced stage (P = 0.002), A positiv e correlation between the cyclin E expression and proliferative activity of tumor cells was Pound (r = 0.896; P < 0.0001), Kaplan-Meier analysis showe d that shorter disease-free and overall survival was significantly associat ed with proliferating cell nuclear antigen (PCNA) overexpression and cyclin E overexpression, When PCNA and cyclin E are combined, the patients with b oth PCNA overexpression and cyclin E overexpression had the poorest prognos es when compared with the other cases. Additionally, in early stage (I-II) cases, cyclin E was also revealed to possess a significant prognostic role. By multivariate analysis, lymph node metastasis and cyclin E overexpressio n were independent prognostic factors for disease-free survival, and tumor size, lymph node metastasis, advanced stage, as well as cyclin E overexpres sion were independent prognostic factors for overall survival. These findin gs indicate that cyclin E overexpression is associated with unfavorable cli nicopathological parameters and represents an independent marker for cell p roliferation and prognosis of LSCC.