Serum creatinine can predict adequacy of peritoneal dialysis - preliminaryreport

Aim: To determine the value of creatinine clearance, estimated using the Co ckcroft and Gault formula, in assessing adequacy of peritoneal dialysis. Me thods: We undertook a retrospective analysis of creatinine clearance result s derived from a conventional 24-hour collection in 35 stable outpatients o n peritoneal dialysis and compared them with those calculated from the corr esponding serum creatinine using the Cockcroft and Gault formula. Results: There was a strong correlation between the 2 methods (r = 0.82, p < 0.0001) , although the formula tended to over-estimate clearances. The formula had a positive predictive value of 88% and a negative predictive value of 86% f or detecting inadequate dialysis. Conclusion: The creatinine clearance calc ulated using the Cockcroft and Gault formula can be used in patients on per itoneal dialysis to estimate adequacy of dialysis. We believe that this met hod, which is far less expensive and time-consuming, deserves further testi ng in a larger population in order to define more accurately its role in th e management of PD patients.