Molecular domains of myelinated axons

Myelinated axons are organized into specific domains as the result of inter actions with glial cells. Recently, distinct protein complexes of cell adhe sion molecules, Na+ channels and ankyrin G at the nodes, Caspr and contacti n in the paranodes, and K+ channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junc tions in the organization of these domains have emerged.