Tetracycline-regulated gene expression in the brain

The possibility of regulating individual gene activities in the mouse brain via the tetracycline-controlled transcriptional activation systems has spa rked the development of novel mouse models aimed at elucidating the molecul ar mechanisms of brain disorders such as Huntington's, prion and Parkinson' s diseases. In the past year, novel experimental strategies and methodologi cal advances have emerged, contributing to the resolution of some of the in itial limitations of these regulatory systems.