Sialic acid imprinted polymer-coated quartz crystal microbalance

Molecularly imprinted polymer-coated sensors for sialic acid were developed using a 9 MHz AT-cut quartz crystal microbalance (QCM). Recognition chips of the sensors used in this study were prepared by coating the two types of sialic acid-imprinted polymers with the use of p-vinylbenzeneboronic acid and/or N,N,N-trimethylaminoethyl methacrylate onto QCM. Each piezoelectric sensor showed a selective response to sialic acid and gave a linear relatio nship between frequency shift and amount of sialic acid from 20 to 250 nmol .