Immune-protective antibodies against capsular polysaccharides do not affect natural competence of Streptococcus pneumoniae: implications for current conjugate vaccination strategies?

Authors
Overweg, K Sluijter, M Srodzinski, M de Groot, R Hermans, PWM
Citation
K. Overweg et al., Immune-protective antibodies against capsular polysaccharides do not affect natural competence of Streptococcus pneumoniae: implications for current conjugate vaccination strategies?, FEMS IM MED, 29(3), 2000, pp. 183-185
Citations number
21
Categorie Soggetti
Immunology
Journal title
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
ISSN journal
09288244 → ACNP
Volume
29
Issue
3
Year of publication
2000
Pages
183 - 185
Database
ISI
SICI code
0928-8244(200011)29:3<183:IAACPD>2.0.ZU;2-J
Abstract
We studied the effect of opsonization or Streptococcus pneumoniae with caps ular antibodies on horizontal transfer of DNA. Opsonization did not inhibit DNA uptake. This suggests that horizontal transfer of capsular genes, whic h is an important escape mechanism of the pathogen. remains a potential thr eat for the efficacy of conjugate vaccination. (C) 2000 Federation of Europ ean Microbiological Societies. Published by Elsevier Science B.V. All right s reserved.